Protein Turnover Atlas™

Cellular protein levels are determined by the interplay between protein synthesis and protein degradation. A comprehensive understanding of these dynamics in a given cell type is central to drug discovery efforts, playing a particularly crucial role in the development of new chemical modalities.

Protein Turnover Atlas™ is a curated repository of proprietary protein half-life data, including modeling of degradation rates, synthesis rates, cell proliferation, and protein copies per cell. Half-lives span from <1 hour to hundreds of hours and cover a diverse range of tissue and disease contexts, including several common cancer-related mutations. The Protein Turnover Atlas™ currently contains half-life data for ~16,000 proteins and more than 25,000 isoforms across 47 cell lines (average of >7,100 protein IDs per cell line).

Its partner database – the Mouse Turnover Atlas™ – provides in vivo turnover data derived from 20 murine tissues and 2 biofluids. This complementary resource includes ~13,500 protein half-lives and over 16,000 isoforms, with high proteome coverage for all tissues/biofluids.