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What is ASMS? Affinity selection mass spectrometry (ASMS) is a powerful technique that enables high-throughput screening of small molecule compounds against a wide range of targets. This technology offers several key advantages, including broad target compatibility, minimal assay development, and no requirement for target or compound labeling. In a typical ASMS experiment, compound libraries are screened against a protein target of interest to identify promising binders. However, ASMS is also extremely well suited for the screening of more specialized target types, such as RNA and DNA...

In a previous blog post, we explored how a comprehensive understanding of protein turnover dynamics can provide crucial...

In the drug discovery and development process, researchers aim to identify a compound that is active against a specific...

A recent article in Science Signaling shines a spotlight on the complex and interconnected world of oncogenic...

Proteomics, or the comprehensive evaluation of the set of proteins present in a specific biological context, is a...

Radiopharmaceuticals, or medicinal compounds that contain radioactive isotopes, represent a potent and attractive...

Targeted quantitative proteomics is a powerful approach to biochemical characterization that leverages mass...