Services - Momentum Biotechnologies

Non-Covalent Binding Assays
Discover and characterize non-covalent leads with affinity selection mass spectrometry (ASMS). This powerful high-throughput approach can rapidly screen compound libraries to identify content that binds target proteins, nucleic acid targets and protein/protein or protein/nucleic acid complexes. Following initial screening, hits can be validated, rank-ordered, and quantitatively analyzed using the same ASMS technology, minimizing assay development time and accelerating innovation.
Covalent Binding Assays
By leveraging the power of intact mass analysis (Intact-MS), covalent compounds can be readily screened in high-throughput. Our automated screening workflow integrates mass spectrometry hardware and analysis tools with in-house custom software to enable throughputs of up to 5K compounds per day. Secondary assays are also available to rank-order compound leads by potency (Kintact/Ki determination) or elucidate sequence selectivity (peptide mapping). Compounds of interest can be followed up in cell lysates or live cells with our activity-based protein profiling services.
Proteomics & Chemoproteomics
We offer an extensive collection of proteomic and chemoproteomic technologies – developed by OmicScouts, A Momentum Biotechnologies Company – that harness the quantitative power of mass spectrometry to deliver actionable biological insights. Our flexible and scalable assay suite enables the system-wide interrogation of protein abundance, turnover, modifications, interactions, and localization across a wide variety of sample types, taking you all the way from discovery and target identification through preclinical work and even exploratory studies of clinical samples.
Small Molecule Analysis
Momentum offers assay development and analysis for small molecule quantification on HPLC-MS, RapidFire-MS, and ICP-MS platforms. The RapidFire-MS system allows ultrafast, automated, label-free functional screening, generating 10,000 datapoints per day and up to 40,000 using BLAZE-mode, while our ICP-MS capabilities enable ultra-sensitive detection of virtually any element or isotope. We can perform biomarker quantification, potency assays, and pharmacokinetic studies, and we have extensive experience measuring lipids, amino acids, sugars, and metabolites.
Oligo Analysis
Momentum has extensive experience in the analysis of nucleic acids by mass spectrometry, allowing us to provide mass determination, purity/impurity analysis, covalent modification characterization. We can also provide specialty workflows, such as RNA cap and tail analyses and oligo sequencing, with industry-leading turnaround time. We routinely work with RNA/DNA oligos that are heavily modified and/or > 100 nucleotides in length.
Data Products
Our on-demand data products enable you to access high-quality, expertly analyzed biological data without the delays of sample preparation and processing. We offer a range of flexible access options, enabling you to obtain exactly the data you need to advance your research program. Tailored interactive reports merge scientific context, data, and visualization to illuminate your protein(s) or cell line(s) of interest.