Covalent Binding Assays

Electrophile Discovery

Unlock novel covalent compounds with direct electrophilic library screening

Automated

Integrated workflows leverage commercial hardware and software for the automated detection of covalent binding

High Throughput

1000s of compounds can be interrogated in 24 hours, while full electrophile library of >10k compounds can be screened in 2-3 days

Quantitative Kinetics

Apparent Kinact/Ki measurement is enabled by similar high-throughput intact MS workflows

Target Versatility

Minor protocol variations enable nucleic acid workflows

Follow-up Characterization

Initial screening can be extended with quantitative adduct mapping, occupancy determination, and more

This assay requires as little as 15 picomoles of protein per data point.

Due to the automation of our data analysis tools, compounds are investigated in singleton.

Our in-house covalent fragment library contains 5,700 compounds in screening-ready format.

Learn More

Learn more about Momentum's mass spectrometry-driven drug discovery services in our digital brochure.

We offer a broad range of services to support all phases of drug discovery and development.

Proteomics & Chemoproteomics
Interrogate protein abundance, activity, and interactions on a global scale with OmicScouts, A Momentum Biotechnologies Company
Small Molecule Analysis
Quantify biomarkers, metals, and more with HPLC-MS, RapidFire-MS, and ICP-MS
Oligo Analysis
Analyze DNA/RNA oligos with superior turnaround time
Data Products
Access proprietary high-quality proteomic databases – no experiments necessary
Non-Covalent Binding Assays
Discover and characterize non-covalent leads with affinity selection mass spectrometry (ASMS)