Oligo Analysis

Momentum has extensive experience in the analysis of oligos by mass spectrometry, enabling a range of services with industry leading turn-around time. By leveraging high-throughput sample preparation, multiple dedicated high-resolution LC-MS instruments, and automated data analysis software, our assays can measure over 5,000 samples a day. We routinely work with RNA/DNA oligos that are heavily modified and/or > 100 nucleotides in length.

Oligo Analysis Services

Mass Determination

Determine the mass of the predominant oligo in a sample

Purity Analysis

Assess the purity of a target oligo

Impurities Analysis

Assess the purity of a target oligo and ascertain the chemical identities of observed impurities

Targeted Component Measurement

Quantify the abundance of target oligos in a sample, including RNA cap and tail analyses

Covalent Modification

Detect and characterize covalent modification(s) of an oligo after treatment with a target compound, including number of modifications and the amount of each modification

Sequencing

Rapid turnaround times ensure you get the answers you need quickly to advance your research program

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Download our digital brochure

Learn more about Momentum's mass spectrometry-driven drug discovery services in our digital brochure.

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Explore Other Services

We offer a broad range of services to support all phases of drug discovery and development.

Data Products
Access proprietary high-quality proteomic databases – no experiments necessary
Non-Covalent Binding Assays
Discover and characterize non-covalent leads with affinity selection mass spectrometry (ASMS)
Covalent Binding Assays
Identify, validate, and prioritize covalent therapeutics with Intact MS and peptide mapping
Proteomics & Chemoproteomics
Interrogate protein abundance, activity, and interactions on a global scale with OmicScouts, A Momentum Biotechnologies Company
Small Molecule Analysis
Quantify biomarkers, metals, and more with HPLC-MS, RapidFire-MS, and ICP-MS